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Deletion of single gene promotes growth of functional lymphatic valves
Foxo1 hereditary lymphedema LEC
2021/8/11
A preclinical study unexpectedly identified the gene Foxo1 as a potential treatment target for hereditary lymphedema. Valve loss or dysfunction that disrupts the flow of lymph fluid is strongly associ...
Accurate prediction of gene expression by integration of DNA sequence statistics with detailed modeling of transcription regulation
gene expression DNA sequence statistics detailed modeling transcription regulation
2011/1/5
Gene regulation involves a hierarchy of events that extend from specific protein-DNA interactions to the combinatorial assembly of nucleoprotein complexes. The effects of DNA sequence on these process...
A robust two-gene oscillator at the core of Ostreococcus tauri circadian clock
two-gene oscillator Ostreococcus tauri circadian clock
2011/1/5
The microscopic green alga Ostreococcus tauri is rapidly emerging as a promising model organism in the green lineage. In particular, recent results by Corellou et al. [Plant Cell, 21, 3436 (2009)] and...
Structures and Assumptions: Strategies to Harness Gene $\times$ Gene and Gene $\times$ Environment Interactions in GWAS
Structures Assumptions Strategies Harness Gene $\times$ Gene Gene $\times$ Environment Interactions in GWAS
2010/11/16
Genome-wide association studies, in which as many as a million single nucleotide polymorphisms (SNP) are measured on several thousand samples, are quickly becoming a common type of study for identify...