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Rat seminal-vesicle secretory protein SVS II binds DNA with a preference for the 5' regulatory region of secretory protein SVS IV gene：co-isolation with components of the nuclear matrix
caltrin nuclear scaffold nuclear structure semen tissue
2009/2/18
In rats, the ventral prostate and seminal vesicles produce distinct sets of proteins whose functions and tissue-specific regulation by androgens remain unclear. We have utilized the genes encoding t...
Characterization of a TPA-response element in the 5'-flanking region of the androgen receptor gene
Steroid receptor gene expression phorbol esters
2009/2/18
The androgen receptor (AR) protein is an important transacting factor that is necessary for mediating gene expression of androgen-responsive genes. The expression of the AR gene is regulated by an...
SP22：a novel fertility protein from a highly conserved gene family
novel fertility protein highly conserved gene family
2009/2/17
Three nucleotide sequences encoding SP22, a protein originally identified in detergent extracts of cauda epididymal sperm, were isolated from a rat testis cDNA library. While two of these cDNA sequenc...
Seminal vesicles are novel sites of luteinizing hormone/human chorionic gonadotropin-receptor gene expression
LH/hCG receptors male accessory organs gonadotropins
2009/2/17
The hypothesis that rat seminal vesicles may contain luteinizing hormone (LH)/human chorionic gonadotropin (hCG) receptors was tested by means of a number of different techniques. Northern blotting ...
Analysis of promoter and androgen regulatory sequences required for optimal transcription of the rat androgen-binding protein gene
Androgen-binding protein (ABP) sex hormone-binding globulin (SHBG) Sertoli cells transcriptional regulation
2009/2/17
The androgen-binding protein (ABP) gene P1 promoter directs cell-specific gene regulation of ABP secreted by Sertoli cells. A recent study using the mouse Sertoli cell line (MSC-1) with a luciferase...
Androgen regulation of the Pem homeodomain gene in mice and rat Sertoli and epididymal cells
Homeobox testosterone promoter testis
2009/2/17
Although the role of homeodomain transcription factors during embryogenesis is well known, their developmental function in postnatal animals is only beginning to be understood. We examined the regul...
Comparison of responses to adrenomedullin and calcitonin gene-related peptide in the feline erection model
ADM CGRP penile erection nitric oxide KATp channe
2009/2/17
The purpose of the present study was to investigate the effects of intracavernosal injections of adrenomedullin (ADM) and calcitonin gene-related peptide (CGRP), two structurally similar peptides,...
Localization and effects of calcitonin gene-related peptide in the testicular vasculature of the rat
CGRP testis blood flow vasomotion
2009/2/17
Using laser Doppler flowmetry, the effects of unilateral intratesticular injection of calcitonin gene-related peptide (CGRP) and CGRP8-37, a CGRP-receptor antagonist, on right- and left-testicular b...
Copulatory behavior and fertility in transgenic male mice expressing human placental growth hormone gene
Sexual behavior placental growth hormone variant
2009/2/17
Male transgenic (TG) mice overexpressing the human placental growth hormone (GH) variant gene (hGH-V) exhibit reproductive deficits in spite of normal testosterone levels and normal sperm counts. ...
Search for androgen response elements in the proximal promoter of the canine prostate arginine esterase gene
Androgenic regulation kallikreins prostate-specific antigen androgen receptor binding
2009/2/13
We have demonstrated the binding of the recombinant DNA binding domain of the rat androgen receptor to a DNA sequence of the canine prostate arginine esterase gene and have determined the functio...
Testis factors that may regulate gene expression: evidence from a patient with Kartagener's syndrome
Kartagener’s syndrome infertility sperm ultrastructure flagella
2009/2/13
Patients with Kartagener's syndrome characteristically have immotile cilia and flagella. Ultrastructural analysis of the efferent ducts of the patient described in this report revealed that the ci...
Human chorionic gonadotropin but not the calcitonin gene-related peptide induces postnatal testicular descent in mice
Cryptorchidism mechanisms androgens paracnne factors gonadotropins testes
2009/2/13
The androgen-regulated paracrine factor, calcitonin gene-related peptide (CGRP), has been proposed as a possible mediator of testicular descent. This peptide has been found to increase rhythmic co...
Gene expression in the aging brown Norway rat epididymis
Gene expression aging brown Norway rat epididymis
2009/2/13
The mammalian epididymis is the site where spermatozoa are matured and then stored. Though many studies have described epididymal functions and their regulation, little is known about how aging af...
Proacrosin gene expression in rat spermatogenic cells
Testis sperm development meiosis acrosome germ
2009/2/12
Mammalian proacrosin gene expression was considered to be exclusively postmeiotic until recent studies detected the presence of proacrosin mRNA in mouse pachytene spermatocytes. To determine if rat ...
Testosterone feedback on gonadotropin secretion and gene expression in transgenic mice expressing human growth hormone gene
Luteinizing hormone follicle-stimulating hormone
2009/2/12
To determine the effects of testosterone on the regulation of gonadotropins in metallothionein-1/human growth hormone (MT/hGH) transgenic mice, basal and gonadotropin-releasing hormone (GnRH)-stim...