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Ultrafast Measurements of Geminate Recombination of NO with Site-specific Mutants of Human Myoglobin
human myoglobin mutagenesis kinetics structure-function relationships picosecond timescale
2016/5/23
Flash photolysis studies of NO recombination to heme proteins offer a direct probe of protein structural changes on the tens of picoseconds timescale where they can be compared with molecular dynamics...
CO Recombination to Human Myoglobin Mutants in Glycerol-Water Solutions
CO Recombination Human Myoglobin Mutants Glycerol-Water Solutions
2016/5/23
The kinetics of CO recombination to site-specific mutants of human myoglobin have been studied by flash photolysis in the temperature range 250-320 K on the nanosecond to second time scale in 75% glyc...
Generation of Fibroblasts Lacking the Sal-like 1 Gene by Using Transcription Activator-like Effector Nuclease-mediated Homologous Recombination
Transcription Activator-like Effector Nuclease [TALEN] Sal-like 1 Gene
2016/5/20
The Sal-like 1 gene (Sall1) is essential for kidney development, and mutations in this gene result in abnormalities in the kidneys. Mice lacking Sall1 show agenesis or severe dysgenesis of the kidneys...
Replication restart in Escherichia coli: Genetic studies at the interface of recombination and replication
DNA replication forks DNA damage proteins cells enzyme catalysis
2015/1/28
DNA replication forks are frequently detained during their progression from oriC to the replication terminus due to encounters with DNA lesions or proteins blocking the way. For survival, cells deploy...
Regulation of RecA-dependent homologous recombination by 3'-5' exonucleases and the UvrD helicase in Escherichia coli K-12
Cell repair DNA damage cell genetic cellular regulation molecular mechanisms
2014/12/11
Homologous recombination is generally considered a major mechanism by which cells repair many types of DNA lesions and damaged replication forks. However, if this process is left unchecked, cells ofte...
中国医科大学生物化学七年制英文版课件Chapter14 Genetic Recombination and Genetic Engineering
中国医科大学 生物化学 七年制 英文版 课件 Chapter14 Genetic Recombination and Genetic Engineering
2014/9/15
中国医科大学生物化学七年制英文版课件Chapter14 Genetic Recombination and Genetic Engineering。
汕头大学医学院五年制本科临床医学生化与分子生物学课件Chapter14 gene recombination and gene engineering
汕头大学医学院 五年制 本科 临床医学生化与分子生物学 课件 Chapter14 gene recombination and gene engineering
2014/6/30
汕头大学医学院五年制本科临床医学生化与分子生物学课件Chapter14 gene recombination and gene engineering。
汕头大学医学院七年制本硕临床医学生化与分子生物学课件Chapter14 gene recombination and gene engineering
汕头大学医学院 七年制 本硕 临床医学生化与分子生物学 课件 Chapter14 gene recombination and gene engineering
2014/6/30
汕头大学医学院七年制本硕临床医学生化与分子生物学课件Chapter14 gene recombination and gene engineering。
Rare events and stochastic tunneling in a two-locus system with recombination
Rare events stochastic tunneling two-locus system
2011/1/5
We study the evolution of a population in a two-locus genotype space, in which the negative effects of two single mutations are overcompensated in a high fitness double mutant. We discuss how the inte...
Red重组系统及在微生物基因敲除中的应用--The Red Recombination System and Its Application to Gene Knock-out in Microorganism
Red重组系统 基因敲除 抗药性基因 Red recombination system gene knock-out resistant gene
2007/12/5
在完成了对各种微生物基因组的测序以后，功能基因学的研究变得尤为重要。研究基因功能最直接的方法便是将待研究的基因失活。最初构建基因突变体是采用大肠杆菌的RecA系统，但是RecA重组系统操作复杂，重组效率低。最近建立了Red重组系统，该系统由3个蛋白组成：α蛋白(即λ核酸外切酶)，β蛋白，Gam蛋白。应用Red系统进行基因敲除，可以直接利用线性打靶DNA，两侧同源臂长度在35~60 bp即可发生同源...
Fast Elimination of Redundant Linear Equations and Reconstruction of Recombination-Free Mendelian Inheritance on a Pedigree
Recombination-Free Mendelian Inheritance Pedigree
2012/11/29
Computational inference of haplotypes from genotypes has attracted a great deal of attention in the computational biology community recently, partially driven by the interna- tional HapMap project. In...
Complexity and Approximation of the Minimum Recombination Haplotype Configuration Problem
Haplotyping, pedigree recombinant SNP complexity approximation,
2012/11/29
We study the complexity and approximation of the problem of reconstructing haplotypes from genotypes on pedigrees under the Mendelian Law of Inheritance and the minimum recombinant principle (MRHC). F...